研究目的
To identify factors associated with intraocular pressure (IOP) reduction following selective laser trabeculoplasty (SLT) in Afro-Caribbean people with primary open-angle glaucoma (POAG).
研究成果
This analysis did not identify any subject-specific factors consistently predictive of therapeutic response to SLT. Of note, no factors predicted a suboptimal response. These findings favorably position SLT for broad application as primary therapy in African-derived people with POAG.
研究不足
The study's sample size was determined based on power analysis to analyze the primary outcome of IOP reduction. Although the sample size was adequate for the current predictive model analysis, a larger sample size may have permitted broader exploration of more potential factors that might be associated with IOP response to SLT.
1：Experimental Design and Method Selection:
A prospective stepped-wedge study design was used to evaluate the efficacy of SLT in Afro-Caribbean subjects with POAG. Multivariable mixed-model analysis was utilized to develop a predictive model for percent IOP reduction 12 months following SLT.
2：Sample Selection and Data Sources:
Data were drawn from 72 Afro-Caribbean subjects with POAG participating in the ongoing West Indies Glaucoma Laser Study.
3：List of Experimental Equipment and Materials:
The Lumenis Selecta II portable slit-lamp mounted laser system was used for SLT treatment.
4：Experimental Procedures and Operational Workflow:
Subjects were randomized to immediate versus 3-month or 6-month delay before 6-week washout of topical IOP-lowering therapy followed by SLT treatment. Posttreatment assessments occurred at 1 hour, 1 week, 1 month, 3 months, and every 3 months thereafter.
5：Data Analysis Methods:
A random mixed-effects model was utilized to characterize longitudinal percent IOP reduction after SLT and to identify factors associated with IOP reduction.
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