摘要： A systematic review was performed through 11 relevant databases. Studies that pertained to pediatric cancer and the effects of physical therapy intervention which were published between the years 2000-2013 were included in this review. Each article was assessed using the AACPDM systematic review tool by four separate researchers. Summary of Use: Patients who undergo treatment for pediatric cancers show an increase in both short and long term impairments, functional problems, and adverse quality of life compared with healthy individuals. These aspects include long term cardiac dysfunction, decreased ankle DF AROM, decreased balance proficiency, decreased function, and decreased in certain aspects of health related quality of life. Physical therapy demonstrates effectiveness in addressing short and long term impairments, functional problems, and decreased quality of life in patients with pediatric neoplasm. Improved scores were shown for knee extension strength as well as scores comparable to healthy controls for ankle dorsiflexion strength. Functional tests such as Timed Up and Down Stairs (TUDS) and 9 minute run-walk test also showed values comparable to healthy controls. This systematic search produced little evidence that demonstrated the optimal time during the cancer treatment course to address impairments, functional limitations, and decreased quality of life. One study produced in our search showed improvements in pediatric cancer patients with concurrent physical therapy intervention. While physical therapy has been shown to effectively treat these issues with feasible interventions for appropriate patients, therapy services are still underutilized in all settings. Importance to Members: This review presents significant information that can be applied to practicing clinicians. Musculoskeletal dysfunction and decreased quality of life are common findings both during and following treatment for pediatric cancers. Although physical therapy has been adequately shown to modulate the physical effects of pediatric cancer treatment, there are still few studies conducted regarding optimal timing and the long term benefit of physical therapy intervention. Therefore, more in depth research should be performed in order to validate current findings on the outcome of physical therapy intervention relating to its positive impact on impairments, functional limitations and quality of life in patients that are undergoing treatment for pediatric cancer.