研究目的
Investigating the opto-acoustic effect of Au nanoparticles in water under the irradiation of pulse laser for potential applications in photothermal therapy and enhancing photoacoustic imaging.
研究成果
The cavitation bubble generated by laser irradiated Au NPs and the opto-acoustic effect of the bubble are investigated theoretically and experimentally. The optimal diameter of Au NP with the largest absorbance is found to be 70 nm. The bubble experiences a damping vibration and releases a damping acoustic wave. The theoretical results coincide with the experimental result qualitatively.
研究不足
The model assumes no interaction among the bubbles induced by different Au NPs and that the opto-acoustic wave of individual bubble can be superposed linearly and coherently. The experimental results coincide with the theoretical results qualitatively but not quantitatively due to the complexity of the real system.
1：Experimental Design and Method Selection:
A model including the Mie theory, gas state equation, Rayleigh-Plesset equation, and sound pressure equation is established to simulate the volume and pressure of the bubble generated by laser irradiated Au NPs.
2：Sample Selection and Data Sources:
Au NPs with different diameters are synthesized through the chemical reaction between HAuCl4 and sodium citrate in water.
3：List of Experimental Equipment and Materials:
A laser with wavelength of 532 nm and pulse duration of 4 ns, a hydrophone (PT-1511312, made by the Institute of Acoustics, Chinese Academy of Sciences), and an oscilloscope (Tektronix Mso4032) are used.
4：Experimental Procedures and Operational Workflow:
The laser is focused by a lens with focal length of 5 cm into the solution containing Au NPs. The acoustic wave generated by the cavitation bubble is detected by the hydrophone and recorded by the oscilloscope.
5：Data Analysis Methods:
The time varying acoustic wave pressure of many Au NPs that distribute randomly in the laser irradiation area is obtained and compared with theoretical simulations.
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