研究目的
To develop a dual-modal fluorescence and magnetic resonance imaging (FI/MRI) probe that combines the high sensitivity of FI and the superior spatial resolution of MRI for more complementary and accurate detection in medical imaging.
研究成果
The Gd-CQDs@N-Fe3O4 nanocomposites were successfully synthesized and characterized, demonstrating potential as a dual-modal imaging probe for both fluorescence and magnetic resonance imaging. The nanocomposites exhibited superparamagnetic properties and suitable relaxivities for MRI contrast enhancement, along with fluorescence emission properties. This integration of FI and MRI modalities could provide more comprehensive imaging information for medical diagnostics.
研究不足
The study did not address the in vivo application or biocompatibility of the Gd-CQDs@N-Fe3O4 nanocomposites, which are crucial for clinical translation. Additionally, the fluorescence intensity of the nanocomposites was significantly reduced compared to the original CQDs, which may limit their application in fluorescence imaging.
1：Experimental Design and Method Selection:
The study involved the synthesis of Gd-doped carbon quantum dots (Gd-CQDs) and their conjugation with amino-functionalized Fe3O4 nanoparticles (N-Fe3O4) to form Gd-CQDs@N-Fe3O4 nanocomposites. The synthesis utilized hydrothermal methods and carbodiimide crosslinking chemistry.
2：Sample Selection and Data Sources:
Citrate acid, ethanediamine, and GdCl3 were used to synthesize Gd-CQDs, while Fe3O4 nanoparticles were synthesized via a solvothermal method and functionalized with AEAPS.
3：List of Experimental Equipment and Materials:
Instruments included a JEOL JEM-2100 TEM, Nicolet Nexus 470 FTIR spectrometer, Shimadzu XRD-6100 X-ray diffractometer, PHI5300 XPS, SQUID VSM, and Varian Cary Eclipse spectrophotometer.
4：Experimental Procedures and Operational Workflow:
Gd-CQDs were synthesized hydrothermally, Fe3O4 nanoparticles were synthesized solvothermally and functionalized, and then conjugated with Gd-CQDs using EDC/NHS chemistry.
5：Data Analysis Methods:
The fluorescence quantum yield was measured using quinine sulfate as a reference. MRI relaxivities were measured on a 0.5T MRI instrument.
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