研究目的
To develop a simple, fast, versatile, and robust method for surface modification of gold nanorods (AuNRs) to facilitate the attachment of various functional ligands, including organic dyes, poly(ethylene glycol)s (PEGs), and DNAs, enabling the assembly of functional biointerfaces.
研究成果
The freeze-induced surface modification method is simple, fast, versatile, and robust, allowing for the attachment of various functional ligands to AuNRs. This method facilitates the assembly of functional biointerfaces and has potential applications in drug delivery, therapeutics, nanostructure fabrication, and plasmonics.
研究不足
The study focuses on the surface modification of AuNRs and does not explore the potential applications in depth. The method's effectiveness with other types of nanoparticles or under different conditions is not investigated.
1：Experimental Design and Method Selection:
A freeze-induced surface modification strategy was proposed for AuNRs to facilitate ligand binding.
2：Sample Selection and Data Sources:
AuNRs were synthesized using a standard seed-mediated method.
3：List of Experimental Equipment and Materials:
Materials included hydrogen tetrachloroaurate (III) hydrate, ascorbic acid, CTAB, DTTC, MUDOL, sodium borohydride, silver nitrate, trisodium citrate dihydrate, thiolated methoxypoly(ethylene glycol), Tris-(2-carboxyethyl) phosphine hydrochloride, phosphate buffered saline, and thiolated oligonucleotides. Equipment included a Shimadzu 2550 UV–vis scanning spectrophotometer, LabRAM HR Evolution confocal microprobe Raman system, Zetasizer Nano ZS-90, ESCALAB 250Xi system, JEOL JEM-1200X transmission electron microscope, and GeminiSEM 300 field-emission scanning electron microscope.
4：Experimental Procedures and Operational Workflow:
AuNRs were synthesized, purified, and then mixed with ligands before freezing. The mixture was thawed, centrifuged, and redispersed in water for characterization.
5：Data Analysis Methods:
UV–vis absorption spectra, Raman spectra, zeta potential, X-ray photoelectron spectroscopy, transmission electron microscopy, and scanning electron microscopy were used for analysis.
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