研究目的
Evaluating the use of Indomethacin, Dexamethasone, and no anti-inflammatory treatment immediately after selective laser trabeculoplasty (SLT).
研究成果
SLT induces little and short-lived inflammation of the anterior segment. The use of NSAID or steroid drops after SLT makes no difference. The IOP-lowering effect of the SLT is equally not influenced by the use of anti-inflammatory medication after laser.
研究不足
Flare laser meter is a more precise manner to register anterior segment inflammation; we used clinical parameters of inflammation because of their clinical significance. SLT seems to induce expression and secretion of interleukins, like ALT does. Upregulating inflammatory pathways may trigger rare cases of corneal edema, corneal decompensation, or macular edema after SLT. Our number of patients is too limited to exclude these complications. So it may still be prudent to use some mild anti-inflammatory medication after SLT.
1:Experimental Design and Method Selection:
Prospective randomized clinical trial of 132 eyes. Both eyes of the patient underwent SLT. One of the eyes was treated with Indomethacin 0.1% or Dexamethasone 0.1% 3 times daily for 1 week; the other eye did not receive any anti-inflammatory treatment.
2:1% or Dexamethasone 1% 3 times daily for 1 week; the other eye did not receive any anti-inflammatory treatment. Sample Selection and Data Sources:
2. Sample Selection and Data Sources: 66 consecutive patients, 132 eyes at the glaucoma consultation at ZNA Jan Palfijn Hospital, Merksem, Belgium. Inclusion criteria concerned primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), or ocular hypertension (OHT) controlled with medical therapy.
3:List of Experimental Equipment and Materials:
A frequency-doubled, Q-switched Nd:YAG laser was used, emitting a wavelength of 532 nm, coupled to a slit-lamp delivery system (Selecta Duet 5; Lumenis, Tel Aviv, Israel).
4:Experimental Procedures and Operational Workflow:
Patients were examined at 1 hour, 1 week, and 1, 3, and 6 months after SLT. They were encouraged to report any discomfort or change in vision. IOP was measured; pain sensation, conjunctival injection, and cells/pigmentation in the anterior chamber were registered.
5:Data Analysis Methods:
A repeated measures ANOVA was executed to investigate the differences in evolution of mean IOP for all groups at all time points. The same time evolution on number of used medications was tested using a Poisson loglinear model.
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