研究目的
Developing a combinatorial therapy nanoplatform that enables dual photothermal therapy and pH-stimulus-responsive chemotherapy for tumor therapy.
研究成果
The MSN@MPN system demonstrates high drug loading capacity, pH-triggered drug release property, excellent photothermal property, and outstanding biocompatibility, making it a promising nanoplatform for combinatorial photothermal therapy and chemotherapy of cancer.
研究不足
The study is focused on in vitro experiments, and further in vivo studies are needed to validate the therapeutic efficacy and safety of the MSN@MPN system.
1：Experimental Design and Method Selection:
The study involves the synthesis of mesoporous silica nanoparticles (MSN) and their super-assembly with metal-phenolic networks (MPN) to create a nanoplatform for drug delivery and photothermal therapy.
2：Sample Selection and Data Sources:
A549 cells (human lung cancer cell line) were used for in vitro studies.
3：List of Experimental Equipment and Materials:
Includes tetraethyl orthosilicate (TEOS), tannic acid (TA), FeCl3, AlCl3, doxorubicin (DOX), and various instruments for characterization and analysis.
4：Experimental Procedures and Operational Workflow:
Synthesis of MSNs, loading of DOX, coating with MPN, photothermal performance tests, pH stimulus-responsive behavior tests, cell viability studies, and cellular uptake studies.
5：Data Analysis Methods:
UV–vis spectrophotometry, fluorescence spectrophotometry, confocal laser scanning microscopy (CLSM), and standard CCK-8 method for cell viability.
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