研究目的
The detection research on H2S, intriguing gas, showed the potential therapeutic implication in the biological and pathological process. However, the above aspect is still in its infancy. The quantified detection of H2S in living cells is crucial in order to understand its biological and pathological roles.
研究成果
In summary, colorimetric fluorescent sensors have been designed and synthesized effectively based on an inorganic-reaction. Two complexes (1, 3) exhibited naked-eye detection for HS– at room temperature and could be used as colorimetric sensor. Complex 4 displayed a remarkable fluorescence enhancement (over 80-fold) and could be performed as fluorescent OFF–ON probe in DMSO and aqueous solutions. Cytotoxicity studies by Hela cells indicated that complex 4 was low cytotoxicity when the concentration was less than 80 μg·mL-1. All these features make the synthesized complexes suitable for the direct monitoring of biologically important HS– in biological samples.
研究不足
The technical and application constraints of the experiments, as well as potential areas for optimization.
