研究目的
Investigating the one-step chlorosulfonylation of alkynes via a photocatalytic redox process to synthesize (E)-selective β-chlorovinyl sulfones.
研究成果
The study presents a novel method for the regio- and stereoselective chlorosulfonylation of alkynes by visible-light-induced photoredox catalysis, offering an operationally convenient alternative to the reported methodologies.
研究不足
All-alkyl substituted alkynes could not participate in the reaction, showing no conversion of starting materials.
1：Experimental Design and Method Selection:
The study employs visible-light-induced photoredox catalysis for the chlorosulfonylation of alkynes.
2：Sample Selection and Data Sources:
A variety of commercially available sulfonyl chlorides and alkynes were used.
3：List of Experimental Equipment and Materials:
The reaction was carried out under a N2 atmosphere at 25 °C for 24 h using fac-Ir(ppy)3 as the catalyst.
4：Experimental Procedures and Operational Workflow:
The reaction conditions were optimized by solvent screening, and the products were isolated by flash silica gel column chromatography.
5：Data Analysis Methods:
Yields were determined by 1H NMR using 1,1,2,2-tetrachloroethane as an internal standard.
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