研究目的
To investigate the impact of depth-dependent optical attenuation on wavelength selection for spectroscopic photoacoustic imaging and to introduce a depth-optimized method for accurate concentration estimation.
研究成果
The depth-optimized wavelength selection method improves the accuracy of SO2 estimation in sPA imaging, especially for deeper imaging targets. The choice of wavelengths is critical, and the proposed method effectively minimizes errors in concentration estimation.
研究不足
The study assumes that the optical fluence distribution is known or can be accurately modeled, which may not always be the case in practical scenarios. The noise model used does not account for all noise sources present in sPA imaging.
1：Experimental Design and Method Selection:
A depth-optimized wavelength selection method was introduced to minimize errors in concentration estimation by considering the optical fluence distribution. Monte Carlo simulations were used to model light propagation in tissue.
2：Sample Selection and Data Sources:
Tissue models with varying depths and concentrations of deoxy-/oxy-hemoglobin were used. Optical fluence maps were acquired for wavelengths ranging from 680 nm to 970 nm.
3：List of Experimental Equipment and Materials:
Monte Carlo program (mcxyz.c) for light propagation simulation, Intel Xeon processor for computation.
4：Experimental Procedures and Operational Workflow:
Optical fluence maps were generated for various wavelengths, SO2 levels, and vessel positions. Noise was added to PA spectra to simulate real conditions.
5：Data Analysis Methods:
Root-mean-square errors (RMSE) of oxy- and deoxy- hemoglobin concentrations were computed to compare the proposed and previous methods.
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