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Relating optical coherence tomography to visual fields in glaucoma: structure-function mapping, limitations and future applications

DOI:10.1111/cxo.12844 期刊:Clinical and Experimental Optometry 出版年份:2018 更新时间:2025-09-11 14:15:04
摘要: Combining information from optical coherence tomography (OCT) imaging and visual field testing is useful in the clinical assessment and monitoring of patients with glaucoma. Measurements of retinal nerve fibre layer thickness or neuroretinal rim width taken around the optic nerve head may be related to the visual field using a structure–function map. In this review, the structure–function mapping methods in clinical use are discussed. Typical clinical maps provide a population average, ‘one size fits all’ representation, but in recent years methods for customising structure–function maps to individual eyes have been developed and these are reviewed here. In the macula, visual field stimuli stimulate photoreceptors for which associated retinal ganglion cells are peripherally displaced. Recently developed methods that relate OCT measurements to visual field test locations in the macula are therefore also reviewed. The use of structure–function maps to relate OCT measurements to localised visual field sensitivity in new applications is also explored. These new applications include the selection of visual field test locations and stimulus intensities based on OCT data, and the formal post-test combination of results across modalities. Such applications promise to exploit the structure–function relationship in glaucoma to improve disease diagnosis and monitoring of progression. Limitations in the validation and use of current structure–function mapping techniques are discussed.
作者: Jonathan Denniss,Andrew Turpin,Allison M McKendrick
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To review and discuss the methods for relating optical coherence tomography (OCT) measurements to visual field test locations in glaucoma, including structure-function mapping, its limitations, and future applications.

The review concludes that combining OCT and visual field information through structure-function mapping can improve glaucoma diagnosis and monitoring. Future innovations may lead to better integration of these modalities, offering more personalized care and earlier disease detection.

Current structure-function mapping methods are limited by the variability in ocular anatomy, measurement errors in anatomical data, and the lack of an objective reference standard for validation. The spatial resolution of customized maps is constrained by the precision of input anatomical measurements.

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