研究目的
To evaluate the effect of cataract extraction on both visual field and retinal nerve fiber layer thickness measurements in primary angle closure glaucoma (PACG) eyes.
研究成果
Both MD and VFI improved after cataract extraction, especially in eyes with pre-operative MD worse than -20 dB. PSD and RNFL thickness showed no significant change after cataract extraction. These findings suggest that cataracts cause a reduction in MD and VFI, and visual field should be interpreted with caution in PACG patients with co-existing cataract. OCT RNFL measured by Spectralis OCT is a useful surrogate in monitoring disease progression in PACG eyes with cataract.
研究不足
The study is limited by its retrospective nature and the small sample size of 30 PACG eyes. Additionally, the effect of cataract extraction on RNFL thickness measurements may vary with different OCT devices.
1:Experimental Design and Method Selection:
Retrospective cohort study on 30 PACG eyes that underwent cataract extraction. Changes in RNFL thickness and visual field parameters including mean deviation (MD), visual field index (VFI) and pattern standard deviation (PSD) were analyzed within 6 months before and after cataract extraction.
2:Sample Selection and Data Sources:
Patients diagnosed with PACG at the Hong Kong Eye Hospital were enrolled between June 2009 to February
3:List of Experimental Equipment and Materials:
20 Humphrey Field Analyzer II (Carl Zeiss Meditec, California, USA) for automated perimetry, Spectralis HRA+OCT (Heidelberg Engineering, Heidelberg, Germany) for RNFL thickness measurements.
4:Experimental Procedures and Operational Workflow:
Static automated white-on-white threshold perimetry was performed using the Humphrey Field Analyzer II. RNFL thickness was measured by spectral-domain optical coherence tomography.
5:Data Analysis Methods:
Statistical analyses were performed using Microsoft Office Excel 2010 and IBM Statistics 20. Continuous variables were expressed as mean ± standard deviation, whilst categorical variables were expressed as individual counts and proportions.
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