研究目的
To calculate the electric field and temperature distribution during one of the most recommended electrotransfer pulsing protocol (i.e. combination of 100 microsecond high-voltage pulse and 400 millisecond low-voltage pulse with pulse lag time of 1 second) in isotropic tissue (e.g. liver) and anisotropic tissue (e.g. skeletal muscle).
研究成果
The proposed model provides useful insight into Joule heating during gene electrotransfer, showing negligible temperature rise in tissue bulk due to high voltage pulse and up to a few °C rise due to the low-voltage 400 ms-long pulse, depending on tissue conductivity.
研究不足
The study is limited to the modeling of Joule heating in tissues during gene electrotransfer using specific pulse protocols and does not account for all possible variations in tissue properties or pulse parameters.
