研究目的
Evaluating the feasibility of in vivo conductivity imaging of mouse tumor from the B1+ phase at 7T using Magnetic Resonance Electrical Properties Tomography (MREPT).
研究成果
The results confirm the possibility of accurate in vivo conductivity assessment in different pathological conditions, which can be used for various medical applications such as hyperthermia treatment planning.
研究不足
The reconstructed conductivity image shows artifact around the boundaries due to the approximation in the Helmholtz equation and discrete calculation of the Laplacian. Further experiments will investigate the effect of signal-to-noise ratio on reconstructed conductivity to stabilize the reconstruction algorithm.
1：Experimental Design and Method Selection:
The study used MREPT for in vivo conductivity imaging, reconstructing electrical conductivity from the B1+ phase. The method was evaluated using homogeneous and heterogeneous phantoms before applying it to a mouse tumor model.
2：Sample Selection and Data Sources:
A phantom with two different conductivity regions and a mouse with a tumor on the forelimb were used. The phantom's conductivity was altered using different concentrations of salt (NaCl).
3：List of Experimental Equipment and Materials:
A 7T Bruker PharmaScan preclinical MR scanner with a quadrature birdcage RF coil, Agilent 85070E coaxial probe, and a PNA-X network analyzer were used.
4：Experimental Procedures and Operational Workflow:
Two 2D spin echo images were used to obtain eddy current corrected B1+ phase images. The conductivity was reconstructed from these images.
5：Data Analysis Methods:
The Savitzky-Golay filter was implemented to calculate the Laplacian of the transmit phase for conductivity reconstruction.
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