研究目的
Developing a novel and efficient method for constructing fluorine-containing γ-keto acid derivatives through combining visible-light photoredox catalysis and chiral Lewis acid catalysis.
研究成果
The study successfully developed a mild and efficient method for the chemo- and stereo-selective synthesis of fluorine-containing γ-keto acid derivatives via merging visible-light photocatalysis and Lewis acid catalysis. The method provides high yields and excellent enantioselectivities for difluoroalkylated products and good to excellent E/Z ratios for monofluoroalkenes.
研究不足
The chemoselectivity of the reaction is highly dependent on the fluorine reagents used, and the method may not be applicable to all types of substrates. The reaction conditions require careful control of light and catalyst loading.
