研究目的
To evaluate the efficacy of photocatalyst antimicrobial coating in reducing methicillin-resistant Staphylococcus aureus (MRSA) acquisition in a high incidence setting.
研究成果
MRSA rate was significantly reduced after photocatalyst coating. Photocatalyst disinfection can be an adjunctive measure to control MRSA acquisition in high-incidence settings.
研究不足
1. General deep cleaning conducted at the end of the year could act as confounding.
2. Active surveillance was conducted only during ICU stay, underestimating incidence rate of MRSA from patients who were discharged ICU within 48 h.
3. Incidence rate of organisms on which active surveillance had not been conducted could have been under- or overestimated.
4. Efforts to enhance hand hygiene and following effect of this strategy had not been performed.
1：Experimental Design and Method Selection:
A prospective cohort study was conducted involving patients hospitalized in a medical intensive care unit. A titanium dioxide-based photocatalyst was coated on high touch surfaces and walls. Five months of pre-intervention data were compared with five months of post-intervention data.
2：Sample Selection and Data Sources:
Patients admitted to the medical ICU during the study period were included, excluding those aged < 18 years and hospitalized less than 72 h.
3：List of Experimental Equipment and Materials:
Titanium dioxide-based photocatalyst, chromogenic media for S. aureus detection, Mueller–Hinton Agar plus cefoxitin, Vitek2 for microorganisms and their antibiotic sensitivities identification.
4：Experimental Procedures and Operational Workflow:
Photocatalyst was uniformly coated on high tough surfaces and walls. Nasal swabs were obtained from patients’ nares up to 48 h after ICU admission and on discharge from ICU.
5：Data Analysis Methods:
The incidence rates of multidrug-resistant organism acquisition and the rates of hospital-acquired infections were compared using Cox proportional hazards regression analysis.
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