研究目的
To test the repeatability and reproducibility of measurements of peri-papillary capillaries from four optical coherence tomography angiography (OCTA) devices.
研究成果
The repeatability of measuring peri-papillary capillaries was high for all four devices, while the reproducibility among the machines was unfavorable. The agreement between Optovue and Triton was fairly good, usually with a higher measurement of VLD for the latter. Longer axial length did not influence the measurement, but increased VLD in the temporal peri-papillary area with longer axial length for Optovue and Triton could result from atrophy in this area and choroidal capillaries segmented into this layer.
研究不足
The measurement of vessels was based on the intensity of pixels, which might include non-vascular signal as vessel density. The sample size for multiple comparison was small. The majority of the participants were young females, limiting the evaluation of age or gender influence on measurements.
1：Experimental Design and Method Selection:
The study was a cross-sectional design involving 109 healthy eyes imaged with four OCTA devices. A 3 × 3 mm scan pattern centered on the disc was repeated twice by each device. En face images of superficial capillary plexus were processed for vessel length density (VLD) calculation.
2：Sample Selection and Data Sources:
Healthy volunteers over 18 years of age with no history of systemic or eye diseases were recruited. Eyes with posterior vitreous detachment and a Weiss’s ring anterior to the disc were excluded.
3：List of Experimental Equipment and Materials:
Four OCTA devices (Spectralis OCT2 module, Angiovue, Triton, and Angioplex) were used. IOL Master was used for axial length measurement.
4：Experimental Procedures and Operational Workflow:
Each eye was imaged using four OCTA devices in a random sequence. Images were processed using Image J software for registration, Hessian filter, auto-threshold, and skeletonization.
5：Data Analysis Methods:
General linear model (GLM) was used to test the impact of device and location on VLD. Intraclass correlation coefficient (ICC) of VLD between repeated scans was calculated.
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