研究目的
To determine if the Bruch’s membrane opening (BMO) location changes over time in healthy eyes and eyes with progressing glaucoma, and to validate an automated segmentation algorithm for identifying the BMO in Cirrus high-definition coherence tomography (HD-OCT) images.
研究成果
The BMO location was stable in normal and progressing eyes indicating that it can be used as a reference plane for the calculation of the ONH parameters to monitor glaucoma progression. However, additional longitudinal datasets with longer follow-up are needed to validate these findings.
研究不足
The relative short follow-up time for the normal and glaucoma groups, and limited age range, particularly of the healthy eyes. The lack of eyes with advanced glaucoma. The study sample size is relatively small. The study did not include high myopic subjects.
1：Experimental Design and Method Selection:
The study followed 95 eyes (35 progressing glaucoma and 60 healthy) for an average of
2：7 years. A stable group of 50 eyes had repeated tests over a short period. BMO points were delineated manually and automatically to assess reproducibility. Sample Selection and Data Sources:
Patients with primary open-angle glaucoma and healthy subjects were recruited from the Diagnostic Innovations in Glaucoma Study (DIGS).
3：List of Experimental Equipment and Materials:
Cirrus HD-OCT 4000 (Carl Zeiss Meditec) was used for imaging.
4：Experimental Procedures and Operational Workflow:
The BMO location variation over time was assessed longitudinally on the aligned images in 3D space point by point in x, y, and z directions.
5：Data Analysis Methods:
Mixed-effects models were used to estimate the location variation of BMO during follow-up.
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