研究目的
Investigating the integration of molecularly imprinted polymers (MIPs) as highly stable biomimetic receptors onto arrays of nanocantilevers for biosensing applications.
研究成果
The study successfully demonstrates the multiplexed functionalization of NEMS with MIPs, showing preserved molecular recognition and mechanical integrity. This approach offers a promising alternative to conventional methods based on biological materials, especially for sensing in harsh environments.
研究不足
The study mentions the challenge of functionalizing free-standing mechanical structures and the need for optimizing NEMS design and polymer thickness for improved sensor performance.
1:Experimental Design and Method Selection:
The study involves the integration of MIPs onto NEMS resonators using spin-coating and photopatterning techniques before releasing the nanostructures.
2:Sample Selection and Data Sources:
Silicon-on-insulator (SOI) wafers were used as substrates for the fabrication of cantilevers' arrays.
3:List of Experimental Equipment and Materials:
Includes a reactive ion etching system, spin coater, automated mask aligner, and atomic force microscopy for characterization.
4:Experimental Procedures and Operational Workflow:
The process involves dry etching of the silicon device layer, silanization, spin-coating of MIP precursor solution, photolithography for patterning, and wet etching for release.
5:Data Analysis Methods:
Fluorescence microscopy and resonant frequency measurements were used to assess molecular recognition and mechanical integrity.
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