研究目的
To measure the reproducibility of speckle-noise freed fluid and tissue compartmentalization of the choroid (choroidal angiography and tissue characterization) using a semiautomated algorithm.
研究成果
Differences in choroidal layers between subjects were found mainly due to alterations in choroidal tissue. Reproducibility of speckle-noise freed choroidal angiography appeared excellent.
研究不足
The study had a relatively small number of subjects and was restricted to young, more-or-less emmetropic females. The image quality was enhanced by using the EDI mode and the averaging of 20 images, resulting in a very long acquisition time. The method can only be used on OCT volume data and not on isolated, two-dimensional B-scans.
1：Experimental Design and Method Selection:
The study included 26 eyes of 13 healthy females, with 13 eyes used for repeated measurements and 13 for side comparison. A semiautomated algorithm was used to remove speckle-noise with structure preservation.
2：Sample Selection and Data Sources:
Healthy females with no ocular pathology were recruited. Exclusion criteria included any ocular pathology, history of ocular trauma, intra- or extraocular surgery, familial eye diseases, or elevated IOP.
3：List of Experimental Equipment and Materials:
A commercially available, standard, SDOCT system (Heidelberg Spectralis) was used for OCT raster scanning.
4：Experimental Procedures and Operational Workflow:
A single experienced ophthalmologist imaged all choroidal volumes using the Heidelberg Spectralis. The scan pattern was raster lines
5：5 x 0 x 9 mm, 261 B-Scans, distance between B-Scans of 12 μm with EDI-mode on. Data Analysis Methods:
Intraclass correlation (ICC) was chosen to define the intrasubject variability of six repeated measurements of the right eye within 1 hour.
独家科研数据包，助您复现前沿成果，加速创新突破
获取完整内容
