研究目的
To evaluate the correlation of the change in glaucoma probability score (GPS) and the stereometric optic nerve head (ONH) parameters of the Heidelberg Retina Tomograph (HRT)3 to an event of glaucomatous progression observed with stereoscopic ONH photography.
研究成果
The correlation of the change in the stereometric ONH parameters with an event of progression was similar between HRT II and HRT3. The change in GPS had limited value in detecting an event of progression. Based on the results, the stereometric parameters that should be used to assess progression include cup volume, vertical cup:disc ratio, cup:disc area ratio, and rim area. Detecting an event of glaucomatous progression should not be based solely on the change in GPS or the stereometric ONH parameters of the HRT. The backwards compatibility between HRT II and HRT3 was good. This allows the detection of a trend of glaucomatous progression, even when changing from HRT II to the next generation of the device during the follow-up of glaucoma.
研究不足
The retrospective nature of the study. As a result, there were significant differences in the follow-up times between patients. A prospective follow-up study would also have allowed more follow-up examinations. In the present study, a trend of progression could not be analyzed due to the limited number of examinations.
1：Experimental Design and Method Selection:
Retrospective follow-up study monitoring subjects with HRT and stereoscopic ONH photographs. Stable, high-quality imaging and at least 18 months of follow-up was required. The topography examinations were acquired using HRT II and calculated with HRT3 software. The event of progression was determined by masked evaluation of stereoscopic ONH photographs.
2：Sample Selection and Data Sources:
Subjects monitored in the Oulu University Hospital with the HRT and stereoscopic ONH photographs. Only the imaging results from 2 visits of each eye were analyzed.
3：List of Experimental Equipment and Materials:
Heidelberg Retina Tomograph (HRT) II and HRT3, Canon CF-60 Uvi fundus camera attached to Canon EOS 1D Mark II, 8MP digital SLR CMOS camera.
4：Experimental Procedures and Operational Workflow:
ONH topography images were acquired using HRT II, with software version
5：The topographies are calculated from 3 scanned images. The images were evaluated using HRT3, with software version 0 and Heidelberg Eye Explorer 0, to calculate the stereometric ONH parameters and the GPS. Data Analysis Methods:
Statistical analysis was carried out using SPSS Statistics 17.0. Logistic regression analysis was the statistical method used. p Values <0.05 were regarded as statistically significant.
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