研究目的
To develop a long-term in vivo glucose sensor using a biocompatible SiC RF antenna for continuous glucose monitoring (CGM) and WiFi applications, addressing the limitations of current glucose monitoring methods.
研究成果
The SiC RF antenna shows promising results as a glucose sensor, with a linear response to glucose concentration changes in vitro. The technology has the potential for long-term, real-time CGM of diabetic patients, offering a non-invasive and pain-free alternative to current methods.
研究不足
The current study is limited to in vitro testing. Future work includes in vivo trials to validate the sensor's performance in a living organism. The sensor's sensitivity and specificity in the presence of other blood components need further investigation.
1：Experimental Design and Method Selection:
Utilized a microstrip patch antenna designed for 10 GHz operation on a semi-insulating biocompatible 4H–SiC substrate. The antenna's performance was tested in vitro using synthetic body fluid and pig blood to simulate different glucose levels.
2：Sample Selection and Data Sources:
Synthetic body fluid and pig blood were used to simulate blood glucose levels. The glucose levels were verified using a conventional glucometer.
3：List of Experimental Equipment and Materials:
Semi-insulating 4H–SiC substrate, Ti/Au metallization, vector network analyzer (VNA HP 8719D), dielectric probe kit (HP85070A), and ANSYS HFSS for simulation.
4：Experimental Procedures and Operational Workflow:
The antenna was tested via reflection coefficient measurements using a VNA. The setup modeled the antenna placed inside a fatty layer in close proximity to blood, with varying glucose concentrations to observe the variation in resonance frequency.
5：Data Analysis Methods:
The shift in resonance frequency was analyzed as a function of glucose concentration, demonstrating the antenna's sensitivity to glucose levels.
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