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Characterization of Retinal Functionality at Different Eccentricities in a Diurnal Rodent

DOI:10.3389/fncel.2018.00444 期刊:Frontiers in Cellular Neuroscience 出版年份:2018 更新时间:2025-09-04 15:30:14
摘要: Although the properties of the neurons of the visual system that process central and peripheral regions of the visual field have been widely researched in the visual cortex and the LGN, they have scarcely been documented for the retina. The retina is the first step in integrating optical signals, and despite considerable efforts to functionally characterize the different types of retinal ganglion cells (RGCs), a clear account of the particular functionality of cells with central vs. peripheral fields is still wanting. Here, we use electrophysiological recordings, gathered from retinas of the diurnal rodent Octodon degus, to show that RGCs with peripheral receptive fields (RF) are larger, faster, and have shorter transient responses. This translates into higher sensitivity at high temporal frequencies and a full frequency bandwidth when compared to RGCs with more central RF. We also observed that imbalances between ON and OFF cell populations are preserved with eccentricity. Finally, the high diversity of functional types of RGCs highlights the complexity of the computational strategies implemented in the early stages of visual processing, which could inspire the development of bio-inspired artificial systems.
作者: María-José Escobar,César Reyes,Rubén Herzog,Joaquin Araya,Mónica Otero,Cristóbal Ibaceta,Adrián G. Palacios
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Investigating the functional differences between central and peripheral retinal ganglion cells (RGCs) in the diurnal rodent Octodon degus to understand how these differences contribute to visual processing.

The study demonstrates that RGCs with peripheral receptive fields are larger, faster, and have shorter transient responses compared to those with central receptive fields. These differences translate into higher sensitivity at high temporal frequencies and a broader frequency bandwidth. The findings highlight the complexity of computational strategies in early visual processing and suggest potential applications in bio-inspired artificial systems.

The study is limited to the diurnal rodent Octodon degus, and findings may not be directly applicable to other species. The analysis of ON and OFF cell populations was constrained by the low percentage of ON cells in the retina preparations.

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