摘要： AIM: To evaluate the detectability of gallbladder stones by dual-energy spectral computed tomography (CT) imaging. METHODS: Totally 217 patients with surgically confirmed gallbladder stones were retrospectively analyzed who underwent single-source dual-energy CT scanning from August 2011 to December 2013. Polychromatic images were acquired. And post-processing software was used to reconstruct monochromatic (40 keV and 140 keV) images, and calcium-lipid pair-wise base substance was selected to acquire calcium base images and lipid base images. The above 5 groups of images were evaluated by two radiologists separately with 10-year experience in CT image reading. In the 5 groups of images, the cases in the positive group and negative group were counted and then the detection rate was calculated. The inter-observer agreement on the scoring results was analyzed by Kappa test, and the scoring results were analyzed by Wilcoxon test, with P < 0.05 indicating that the difference was statistically significant. The stone detection results of the 5 groups of images were analyzed by χ2 test. RESULTS: There was good inter-observer agreement (k = 0.772). In 217 patients with gallbladder stones, there was a statistically significant difference in stone visualization between spectral images (40 keV, 140 keV, calcium base and lipid base images) and polychromatic images (P < 0.05). 40 keV monochromatic images were better than 140 keV monochromatic images (4.90 ± 0.35 vs 4.53 ± 1.15, P < 0.05), and calcium base images were superior to lipid base images (4.91 ± 0.43 vs 4.77 ± 0.63, P < 0.05), but there was no statistically significant difference between 40 keV monochromatic images and calcium base images (4.90 ± 0.35 vs 4.91 ± 0.43, P > 0.05). In 217 gallbladder stone patients, there were 21, 3, 28, 5 and 12 negative stone cases in polychromatic images, 40 keV images, 140 keV images, calcium base images and lipid base images, respectively, and the differences among the five groups were statistically significant (P < 0.05). CONCLUSION: Monochromatic images and base substance images have a good clinical prospect in the iso-density stone detection.