研究目的
To develop multifunctional nanoplatforms for enhanced photo-radio combined therapy in the second biological window using two-dimensional core-shell MXene@Gold nanocomposites.
研究成果
The 2D core-shell Ti3C2@Au nanocomposites were successfully synthesized and demonstrated enhanced optical absorption, improved stability, and biocompatibility. They were effectively used for PA/CT dual-modal imaging and showed significant potential in photothermally enhanced radiotherapy with improved tumor oxygenation and minimal toxicity.
研究不足
The study focuses on the synthesis and preliminary in vitro and in vivo evaluation of Ti3C2@Au nanocomposites. Long-term toxicity and clinical applicability require further investigation.
1：Experimental Design and Method Selection:
The study synthesized Ti3C2@Au nanocomposites via a seed-growth method starting from Ti3C2 nanosheets. The nanocomposites were modified with thiol groups to improve stability and biocompatibility.
2：Sample Selection and Data Sources:
Ti3AlC2 nanosheets were etched by hydrofluoric acid (HF) to remove the Al layer, and then Ti3C2 nanosheets were obtained by adding TPAOH organic alkali.
3：List of Experimental Equipment and Materials:
Transmission electron microscope (TEM), scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray diffraction (XRD), UV-vis-NIR spectrophotometer, dynamic light scattering (DLS), and zeta potential analyzer.
4：Experimental Procedures and Operational Workflow:
The synthesis involved modifying Ti3C2 nanosheets with PAH, adsorbing Au seeds, and growing a dense Au shell. SH-PEG was used for surface modification.
5：Data Analysis Methods:
The optical properties, photothermal effects, and therapeutic efficiency were analyzed using various imaging and spectroscopic techniques.
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