研究目的
To evaluate the use of in vivo confocal microscopy (IVCM)-MGD description to classify patients affected by clinical MGD and measure the correlation with standard clinical criteria and subjective symptoms.
研究成果
The new IVCM classification provided a practical pathophysiological system for MGD, helping to understand patients' symptoms and enhance treatment effectiveness. The classification was correlated with clinical tests and meibography score, indicating its utility in diagnosing and managing MGD.
研究不足
IVCM explores only the terminal part of the inferior tarsus with a 400 × 400-μm field, whereas meibography can explore the entire superior and inferior tarsus. The study is not prospective, so it cannot confirm whether MGD evolves from type 1 to type 2 and 3 or if treatment could prevent this progression.
1：Experimental Design and Method Selection:
The study included 100 eyes of 100 patients with MGD and 15 eyes of normal subjects. A comprehensive evaluation was performed using OSDI, Schirmer test, TBUT, tear osmolarity, Oxford score, Meibomian gland expression, palpebral IVCM, and meibography.
2：Sample Selection and Data Sources:
Patients were diagnosed with MGD based on OSDI>13, signs of posterior blepharitis, and abnormal meibum expression. Normal subjects had no blepharitis, OSDI≤13, and normal meibum expression.
3：List of Experimental Equipment and Materials:
Heidelberg RetinaTomograph II-Rostock Cornea Module (HRTII-RCM) for IVCM, Oculus Keratograph 5M? for meibography.
4：Experimental Procedures and Operational Workflow:
IVCM was performed on the most affected eye after topical anesthesia. Meibography was performed to evaluate meibomian gland morphology.
5：Data Analysis Methods:
Statistical analyses were done using SAS 9.4, with demographic and clinical characteristics reported as mean ± standard deviation for quantitative data, and frequencies and proportions for categorical data.
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