1：Experimental Design and Method Selection:

The study involved designing nanocomposite hydrogels using PEGDA macromers crosslinked via singlet oxygen generated by PSiNPs under NIR light irradiation. Methods included electrochemical etching, ultrasonication, UV-vis spectroscopy, FTIR, SEM, thermal imaging, and cellular assays.

2：Sample Selection and Data Sources:

Silicon wafers were used to fabricate PSiNPs; Hela cancer cells were cultured for in vitro tests. Data were sourced from experimental measurements and observations.

3：List of Experimental Equipment and Materials:

Silicon wafers (p-type, boron doped, 8–10 Ω cm resistivity), PEGDA (Mn ≈ 575), DPBF, RB, DOX, HF/ethanol mixture, NIR laser (808 nm, Hi-Tech Optoelectronics), UV-vis spectrophotometer (Lambda 950, PerkinElmer), FTIR (Vertex 80, Bruker), SEM (FEI QUANTA 200), microplate photometer (Filter Max F5, Molecular Devices), thermal monitoring system (MG33, Shanghai Magnity Electronics), LSCM (LSM710 NLO, Zeiss).

4：Experimental Procedures and Operational Workflow:

PSiNPs were fabricated via electrochemical etching and ultrasonication. Hydrogels were formed by irradiating PSiNPs/PEGDA mixtures with NIR laser. Singlet oxygen detection used DPBF probe. Photothermal effects, DOX release, biodegradation, and cellular assays (MTT, staining) were conducted step-by-step.

5：Data Analysis Methods:

UV-vis spectra for DPBF decay and DOX release, FTIR for crosslinking, SEM for morphology, thermal imaging for temperature changes, MTT assay for cell viability, and LSCM for fluorescence imaging. Statistical analysis included standard deviations.