研究目的
To develop a real-time photoacoustic tomography imaging system, produce a phantom with contrast media, observe their reactions to varying light wavelengths, and apply selective filtering to enhance object detection and reduce noise in the images.
研究成果
The real-time PAT system successfully acquired images, with contrast media showing specific wavelength reactions. Selective filtering improved object detection and noise reduction, but object shape was not maintained. Future work should explore more contrast media and wavelengths, and improve the filtering technique to preserve shape.
研究不足
The morphological opening operation caused objects to lose their original shape due to the structural components used. Superparamagnetic iron oxide did not react at the wavelengths tested. The study was limited to specific contrast media and wavelength ranges, and the filtering technique may require optimization for better shape preservation.
1：Experimental Design and Method Selection:
The study involved designing a real-time PAT image acquisition system using a linear array transducer and a back projection algorithm for image reconstruction. Selective filtering techniques, including morphological opening, Otsu's thresholding, nonlinear anisotropic filtering, and median filtering, were applied to process the images.
2：Sample Selection and Data Sources:
A phantom was created using gelatin to mimic biological tissues, with tubes containing methylene blue, indocyanine green, gold nanoparticle, and superparamagnetic iron oxide as contrast media. PAT images were acquired at wavelengths from 700 nm to 900 nm.
3：List of Experimental Equipment and Materials:
Equipment included a PXI-based DAQ device, a linear array probe with 128 transducers at 5 MHz, a custom laser trigger controller, a 128-channel preamplifier, an Nd:YAG Q-switched laser (NT352-A20-AW, EKSPLA), and a fiber optic line light (NT57-019, Edmund Optics). Materials included gelatin, polymer tubes, and the contrast media.
4：Experimental Procedures and Operational Workflow:
The PAT system was synchronized for laser radiation, signal acquisition, and image conversion. Images were acquired at different wavelengths, and selective filtering was applied to enhance object areas and remove noise.
5：Data Analysis Methods:
Quantitative analysis included calculating root mean square error (RMSE), peak signal-to-noise ratio (PSNR), and mean absolute error (MAE) to compare filtering methods.
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