1：Experimental Design and Method Selection:

Synthesis of non-symmetric 2,1,3-benzothiadiazole compounds via Sonogashira cross-coupling reactions. Characterization using NMR, mass spectrometry, IR spectroscopy, differential scanning calorimetry (DSC), polarized optical microscopy (POM), X-ray diffraction (XRD), thermogravimetric analysis (TGA), UV-vis and fluorescence spectroscopy.

2：Sample Selection and Data Sources:

Compounds 6a-f were synthesized and studied; symmetric compounds 3a-f from previous studies were used for comparison.

3：List of Experimental Equipment and Materials:

Instruments include Bruker VERTEX 70/70V IR spectrometer, Varian Mercury Plus NMR spectrometers, MicrOTOF QII mass spectrometer, Olympus BX50 microscope with Mettler Toledo FP-82 hot stage, DSC-Q2000 calorimeter, Shimadzu TGA-50, X'Pert-PRO XRD diffractometer, Varian Cary 50 UV-vis spectrophotometer, Shimadzu RF5301pc spectrophotometer, Ocean Optics USB4000 spectrophotometer, Hitachi-F-7000 spectrofluorimeter. Materials include silica gel for chromatography, solvents like chloroform, and reference standards like quinine sulfate.

4：Experimental Procedures and Operational Workflow:

Synthesis involved multi-step reactions; thermal analysis was done with heating/cooling cycles at 10°C/min; photophysical measurements were conducted in solution and thin films; temperature-dependent fluorescence was measured using a hot stage and UV lamp.

5：Data Analysis Methods:

Data analyzed using software like ChemBio3D Ultra for molecular length estimation; Lippert-Mataga equation for solvatochromism; quantum yields calculated relative to quinine sulfate; band gaps estimated from absorption spectra.