研究目的
To concurrently evaluate the effect of half-fluence photodynamic therapy (hf PDT) on choriocapillaris (CC) perfusion and choroidal structure in chronic central serous chorioretinopathy (CSC).
研究成果
OCTA demonstrates a significant increase in choriocapillaris perfusion one month after hf-PDT, indicating that hf-PDT affects larger choroidal vessels while sparing CC flow, reducing concerns about choroidal ischemia. The decrease in luminal areas is attributed to reduced large-caliber vessels.
研究不足
The study did not include immediate post-treatment data, limiting conclusions on short-term CC changes. Sample size was moderate, and some patients did not complete all follow-ups. Diurnal variations were controlled but not eliminated.
1：Experimental Design and Method Selection:
This prospective interventional study used enhanced depth imaging optical coherence tomography (EDI-OCT) and optical coherence tomography angiography (OCTA) to analyze choroidal changes after hf-PDT in chronic CSC patients. Image J software was employed for binarization and area calculations.
2：Sample Selection and Data Sources:
48 eyes of 41 patients with chronic CSC were included, with exclusion criteria such as symptom duration less than 3 months, previous PDT, and other ocular diseases. Data were collected from the Ophthalmology Department of Ankara University School of Medicine.
3：List of Experimental Equipment and Materials:
Spectralis? SD-OCT with EDI module (Heidelberg Engineering Inc.), Avanti RT Vue XR? OCTA with AngioVue? software (Optovue Inc.), Zeiss Visulas 690S PDT Laser System, verteporfin (Visudyne?), Image J software (version
4：50a), and Volk? area centralis contact lens. Experimental Procedures and Operational Workflow:
Patients underwent ophthalmic examinations including BCVA, slit-lamp biomicroscopy, dilated fundus exam, SD-OCT, and OCTA at baseline and 1, 3, 6 months post-hf-PDT. PDT was administered with half-fluence protocol. Image analysis involved manual border setting and binarization with Niblack method.
5：Data Analysis Methods:
Statistical analysis used paired-sample t-test, Wilcoxon test, and SPSS software (version 15.0) with significance at p < 0.05.
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