研究目的
To develop a portable system for guiding and monitoring photodynamic therapy (PDT) in oral cancer treatment using a smartphone application and an intraoral camera to improve treatment efficiency and outcomes.
研究成果
The developed system successfully demonstrated the feasibility of using a modified endoscopy camera and smartphone application for PDT guidance and monitoring in oral cancer, showing higher contrast in photosensitizer samples. Future work involves clinical evaluation in high-incidence regions to improve PDT outcomes.
研究不足
The system was tested in a controlled lab environment with simulated samples, not yet evaluated in clinical settings; potential limitations include variability in real oral cavity conditions, need for further validation, and dependence on smartphone and camera hardware.
1：Experimental Design and Method Selection:
The study involved designing a smartphone application to process images from a modified endoscopy camera for PDT guidance and monitoring, utilizing fluorescence imaging principles and image processing techniques.
2：Sample Selection and Data Sources:
Tested with solutions of protoporphyrin IX (PpIX) as a photosensitizer and titanium dioxide as a control substance, poured into small containers to simulate tissue conditions.
3：List of Experimental Equipment and Materials:
Endoscopy camera, smartphone (Android device), LEDs (405 nm), resistors (200 Ω, 0603 packaging), AA batteries, optical filter, 3D-printed body, PCB, and software tools (Java, XML, OpenCV, UVC Camera library).
4：Experimental Procedures and Operational Workflow:
Images were captured with the camera under violet LED excitation, processed in the app to extract red channel, apply multicolor table, and adjust contrast/brightness; results were analyzed for contrast enhancement.
5：Data Analysis Methods:
Qualitative analysis of image contrast between photosensitizer and control samples using the smartphone application's processing capabilities.
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