研究目的
To develop a polydopamine-based tumor-targeted multifunctional reagent for dual-mode bioimaging-guided photothermal therapy.
研究成果
The FEDA nanoparticles demonstrated high grafting efficiency, excellent dual-mode imaging capabilities, effective photothermal therapy with a conversion efficiency of 32.3%, good tumor targeting, and low toxicity, making them promising for clinical diagnostic and therapeutic applications.
研究不足
Potential limitations include the specificity of tumor targeting, long-term biocompatibility, and scalability for clinical use.
1：Experimental Design and Method Selection:
Utilized surface-initiated atom transfer radical polymerization (ATRP) strategy to graft europium(III) complexes onto polydopamine (PDA) nanoparticles modified with folic acid (FA) for targeted tumor therapy and imaging.
2：Sample Selection and Data Sources:
Used 4T1 cancer cells and mice models for in vitro and in vivo studies.
3：List of Experimental Equipment and Materials:
Included TEM, SEM, XPS, FT-IR, UV-vis/NIR spectroscopy, confocal laser scanning microscopy (CLSM), ICP-AES, and an 808 nm NIR laser.
4：Experimental Procedures and Operational Workflow:
Synthesized PDA nanoparticles, modified with FA and CPA, grafted Eu complexes via ATRP, characterized nanoparticles, conducted cytotoxicity assays, photothermal therapy tests, and imaging studies.
5：Data Analysis Methods:
Analyzed data using various spectroscopic and imaging techniques to evaluate efficiency and effects.
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Transmission Electron Microscope
Characterization of nanoparticle size and morphology
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Scanning Electron Microscope
Characterization of nanoparticle size and morphology
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X-ray Photoelectron Spectrometer
Chemical composition analysis
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Fourier Transform Infrared Spectrometer
Functional group analysis
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UV-vis/NIR Spectrophotometer
Absorption spectroscopy analysis
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Confocal Laser Scanning Microscope
Cellular internalization imaging
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Inductively Coupled Plasma Atomic Emission Spectrometer
Elemental analysis for biodistribution
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NIR Laser
808 nm
Photothermal therapy irradiation
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