研究目的
To produce a surface-dosimetry method capable of accurately and remotely measuring skin dose for patients undergoing total skin electron therapy (TSET) without the need for postexposure dosimeter processing, improving clinical workflow.
研究成果
Scintillator-based surface dosimetry accurately reports dose within <3% of OSLDs in most cases, offering a rapid, wireless alternative that reduces time and resources for multisite dosimetry in TSET, with potential for integration into medical records to minimize human error.
研究不足
The system is not applicable to sites needing radiation boost by complementary fields (e.g., soles of feet or groin) as they are not visible. Angular dependence beyond 80 degrees requires correction, and camera stability must be monitored for radiation damage over time.
1：Experimental Design and Method Selection:
A linear accelerator-synchronized, time-gated, intensified camera was used to image scintillator targets attached to patients' skin during TSET delivery. Real-time image processing included background subtraction, filtering, and dose conversion using a custom algorithm.
2：Sample Selection and Data Sources:
Three patients undergoing TSET for mycosis fungoides and Kaposi sarcoma were included, with dosimetry sites on upper arm, lower arm, chest, midsection, midthigh, midshin, and upper foot. OSLDs served as absolute dose references.
3：List of Experimental Equipment and Materials:
Intensified camera (C-Dose Research; DoseOptics), Canon EF 24-mm f/
4：4L II USM lens, scintillator discs (EJ-212 plastic, Eljen Technologies), OSLDs (nanoDot, Landauer Inc), TLDs (TLD-100 rods, ThermoFisher Scientific), linear accelerator (Trilogy, Varian Medical Systems). Experimental Procedures and Operational Workflow:
Scintillators and OSLDs were attached to patients, imaged during TSET at 7 frames per second under standard room-light conditions. Images were processed in real-time to extract scintillation signals and convert to dose.
5：Data Analysis Methods:
Data were analyzed using MATLAB for fitting Gaussian-convolved-ellipse functions to scintillator regions of interest, summing amplitudes, and applying calibration factors to compute dose. Percent differences and linear regressions were calculated between scintillator and OSLD doses.
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