1：Experimental Design and Method Selection:

A UV spectrophotometric method using simultaneous equations was developed. The method involved selecting two analytical wavelengths (315 nm and 258 nm) where each drug has maximum absorbance, and using absorptivity values to solve simultaneous equations for concentration determination.

2：Sample Selection and Data Sources:

Pure ranitidine hydrochloride and itopride hydrochloride were used as samples, obtained as gifts from Strides Acrolab and Themis Pharma Pvt Ltd, respectively. Standard solutions were prepared in double distilled water.

3：List of Experimental Equipment and Materials:

Double beam UV-Vis spectrophotometer (Shimadzu Pharmaspec 1700), volumetric flasks, pipettes, beakers, analytical balance (Dwijo, 200 G), cuvettes (1 cm path length), distilled water from Barnstead distillation apparatus.

4：Experimental Procedures and Operational Workflow:

Stock solutions of 1000 μg/ml were prepared and diluted to working standards. Absorbance was measured at 315 nm and 258 nm for pure drugs and mixtures. Simultaneous equations were constructed and solved using Cramer's rule with MS Excel and VB applications.

5：Data Analysis Methods:

Linear regression was used to determine absorptivity values. Statistical validation included specificity, linearity, precision, accuracy, LOD, LOQ, and range calculations.