1：Experimental Design and Method Selection:

Two types of reactors were designed: MSP assisted sonochemical flow loop reactor (reactor 1) for synthesizing ZnO nanoparticles (ZnO-NPs) and MSP assisted sonochemical mixing reactor (reactor 2) for synthesizing ZnO nanoleaves (ZnO-NLs). Both reactors utilize bath sonication and mechanical mixing via MSPs to enhance reaction homogeneity and scalability.

2：Sample Selection and Data Sources:

Zinc acetate dihydrate and sodium hydroxide were used as precursors. Gram-positive bacteria Staphylococcus aureus was used for antibacterial testing. Various papers (parchment, office, nylon membrane, PVDF filter) were used for anti-counterfeiting tests.

3：List of Experimental Equipment and Materials:

Equipment includes bath sonicator (Limplus LA-10L, 200W, 33+3 KHz), MSPs (9W and 18W), UV-visible spectrophotometer (Perkin-Elmer Lambda), fluorescence spectrophotometer (F-2500 FL Spectrophotometer), HR-XRD (Smartlab Rigaku), FTIR (3000 Hyperion Microscope with vertex 80 FTIR system), FEG-TEM (Jeol JEM-2100F), FEG-SEM (JSM-7600F), TGA (Perkin Elmer Diamond TG/DTA), BET surface area analyzer (SMART SORB 92/93), and others. Materials include chemicals from Sigma-Aldrich and HIMEDIA, filter papers from Merck Millipore and Pall Life Sciences, cotton fabric, rubber stamps, fountain pens.

4：Experimental Procedures and Operational Workflow:

For reactor 1, MSP (18W) was used to establish a flow loop between a submersible tank and bath sonicator; zinc acetate solution was mixed, NaOH added to pH 11, sonicated for 2h, centrifuged, washed, dried. For reactor 2, MSP (9W) provided mechanical mixing during sonication; similar steps as reactor 1 but with continuous exposure. ZnO-NPs were coated on cotton fabric via sonication. Antibacterial activity was assessed using spread plate method with CFU analysis. Anti-counterfeiting ink was prepared by dispersing ZnO-NLs in ethanol and tested on papers.

5：Data Analysis Methods:

UV-visible and fluorescence spectra were analyzed for optical properties. XRD and FTIR for structural and chemical analysis. Electron microscopy for morphology. TGA for thermal stability. BET for surface area. Statistical analysis using ImageJ for particle size distribution.