研究目的
To systematically review and summarize the literature on the use of photobiomodulation (PBM) devices at home for nonesthetic medical applications, addressing the gap in published reviews on this subject.
研究成果
Home-use PBM devices show promise for effective and safe treatments in various medical conditions requiring frequent applications, such as pain, wound healing, and cognitive dysfunction. However, conclusive evaluation of efficacy necessitates additional well-designed, randomized controlled studies with adequate power and long-term follow-up to validate these findings and support clinical adoption.
研究不足
The limitations include the small number of studies (only 11 included), variability in study designs (e.g., small RCTs and case series), lack of large-scale randomized controlled trials, and potential bias in non-randomized studies. Funding constraints and proprietary information on device dosages also limit the depth of analysis.
1：Experimental Design and Method Selection:
The review followed PRISMA guidelines and was registered in PROSPERO. A systematic literature search was conducted using PubMed and Embase without language or date restrictions, with keywords related to PBM and home use. Manual searches of references and conference abstracts were also performed. Inclusion criteria included prospective studies, case series, or case reports on nonesthetic PBM devices used at home at least thrice a week. Exclusion criteria included cosmetic indications, reviews without new data, clinic-only use, laser acupuncture, and devices emitting blue or ultraviolet light.
2：Sample Selection and Data Sources:
Studies were screened by title and abstract, then full text, with data extraction on study design, indication, participants, device parameters, treatment protocol, and findings.
3：List of Experimental Equipment and Materials:
Various PBM devices were used, including lasers and LEDs from brands like Virulite, B-cure diode laser, LumiPhase-R Compact, Vielight, WARP10, MedX home, Anodyne Therapy Professional System, and Amcor device.
4：Experimental Procedures and Operational Workflow:
Two independent reviewers screened and extracted data, with disagreements resolved by discussion. Treatment dosages were compared to WALT recommendations, and efficacy was evaluated based on primary endpoints for specific indications.
5：Data Analysis Methods:
Data were synthesized by grouping device parameters and indications, with efficacy assessed per indication. Risk of bias was minimized through protocol registration, adherence to PRISMA, manual searches, independent review, evidence grading, and conflict disclosure.
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