研究目的
To assess the influence of central corneal thickness (CCT) and corneal curvature in tonometry measurements taken by Goldmann applanation tonometry (GAT) and Pascal dynamic contour tonometry (DCT).
研究成果
GAT consistently underestimates IOP compared to DCT, with the difference being greater in thinner corneas. Flat corneal curvature also affects GAT measurements, while DCT is less influenced by corneal properties, suggesting it could be a more reliable method, especially post-refractive surgery.
研究不足
The study is limited to a specific patient population in one clinic, and measurements may be influenced by examiner experience and device calibration. Only eyes with acceptable DCT quality scores were included, potentially excluding some data.
1:Experimental Design and Method Selection:
Prospective study design to compare IOP measurements using GAT and DCT tonometers, assessing the influence of CCT and corneal curvature. Statistical methods include descriptive analysis, ANOVA, correlation coefficients, and Bland-Altman plots.
2:Sample Selection and Data Sources:
185 eyes from 97 subjects attending outpatient ophthalmology appointments. Selection criteria not specified beyond attendance.
3:List of Experimental Equipment and Materials:
Goldmann applanation tonometer, Pascal dynamic contour tonometer, ultrasound pachymeter (OcuScan RXP), Orbscan IIZ Corneal Analysis System, slit lamp (Haag-Streit AG), topical anesthesia, fluorescein.
4:Experimental Procedures and Operational Workflow:
IOP measurements taken with GAT and DCT in randomized order with 10-minute interval. GAT: three readings per eye with 5-minute intervals, mean recorded. DCT: two readings with quality scores Q1 or Q2 considered. CCT measured 20 minutes after IOP with ultrasound pachymeter, two measurements averaged if SD <2.0. Corneal curvature measured with Orbscan.
5:Corneal curvature measured with Orbscan.
Data Analysis Methods:
5. Data Analysis Methods: Statistical analysis using SPSS version 21, including Spearman correlation, ANOVA, ICC, Bland-Altman plots, and Tukey's test.
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