研究目的
To describe the clinical features and fundus autofluorescence (FAF) and spectral-domain optical coherence tomography (OCT) findings of two consecutive patients with optic disk melanocytoma (ODM).
研究成果
The OCT findings in the reported cases are consistent with literature, showing sloped and reflective anterior tumor surface, retinal disorganization, and posterior shadowing. FAF revealed hypoautofluorescence at the tumor area and isoautofluorescence elsewhere, which is a novel finding for melanocytomas. This suggests FAF could be a useful tool for diagnosis and follow-up in suspicious cases, potentially reducing misdiagnosis, but further studies with larger samples are needed to confirm these patterns.
研究不足
The study is limited by its small sample size (only two patients), which may not capture the full variability of ODM presentations. The retrospective nature and lack of histopathological confirmation could affect the generalizability of findings.
1：Experimental Design and Method Selection:
A retrospective study was conducted by reviewing medical records and ophthalmic imaging examinations of two patients with ODM. The methods included color and red free retinography, fundus autofluorescence (FAF), fluorescein angiography (FA), and spectral-domain optical coherence tomography (OCT).
2：Sample Selection and Data Sources:
Two consecutive patients diagnosed with ODM and referred to an ophthalmic oncology specialist at Hospital Universitário Professor Edgard Santos, Salvador (BA), Brazil, within a three-month period (June-September, 2012). Data were sourced from medical records and imaging examinations performed at the Retina and Vitreous service of Hospital S?o Rafael (Funda??o Monte-Tabor), Salvador (BA), Brazil.
3：2). Data were sourced from medical records and imaging examinations performed at the Retina and Vitreous service of Hospital S?o Rafael (Funda??o Monte-Tabor), Salvador (BA), Brazil.
List of Experimental Equipment and Materials:
3. List of Experimental Equipment and Materials: Topcon TRC-50DX retinal camera and Optovue-RTVue 100 spectral-domain OCT device were used for imaging.
4：Experimental Procedures and Operational Workflow:
Patients underwent ophthalmological examination, ancillary procedures (color and red free retinography, FAF, FA, OCT), and data collection by the same ophthalmologist. Imaging was performed to assess tumor characteristics.
5：Data Analysis Methods:
Demographics, clinical data, and imaging findings were described and compared with relevant literature. Findings were analyzed for consistency with known patterns.
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