1：Experimental Design and Method Selection:

The study involved designing two PET system configurations (A and B) with dual-layer offset structures for depth of interaction (DoI) detection. Methods included using silicon photomultipliers (SiPMs) and lutetium oxyorthosilicate (LSO) crystals, with Anger logic for crystal identification and data processing in MATLAB.

2：Sample Selection and Data Sources:

Existing LSO crystal arrays from Agile Engineering were used, irradiated by a 22Na source for measurements.

3：List of Experimental Equipment and Materials:

Equipment included SiPM arrays (e.g., S11828-3344M, S10985-050P(X)), optical diffusors, LSO crystals, preamplifiers (ADA4895), ADCs (V1742), constant fraction discriminators (CFD 102), and a PMT detector (R9800). Materials included optical grease (BC630) and reflector foil (Vikuiti).

4：0). Materials included optical grease (BC630) and reflector foil (Vikuiti). Experimental Procedures and Operational Workflow:

4. Experimental Procedures and Operational Workflow: For singles acquisition, the detector was irradiated without collimation; for timing resolution, a coincidence setup with a PMT was used. Signals were amplified, digitized, and processed to evaluate energy resolution, position profile, peak-to-valley ratio, and timing resolution. Measurements were conducted at 20°C in a dark box.

5：Data Analysis Methods:

Data was processed in MATLAB, using baseline correction, Gaussian fits for energy resolution, semi-automated peak finding for position profiles, and interpolation for timing resolution. Anger logic equations were applied for coordinate calculation.