1：Experimental Design and Method Selection:

The study involved designing a lanthanide MOF (LMOF) with dual-emission centers for ratiometric sensing of HVA. The probe was synthesized under hydrothermal conditions, and its sensing capabilities were evaluated through fluorescence spectroscopy. A logic gate operation was integrated to process the fluorescence signals for intelligent sensing.

2：Sample Selection and Data Sources:

HVA and other serum constituents (e.g., glucose, creatinine, NaCl) were used as analytes. Goat serum was pretreated with acetonitrile to remove proteins for real-sample testing.

3：List of Experimental Equipment and Materials:

Equipment included Bruker D8 diffractometer (XRD), Tensor 27 FTIR spectrometer, Cary 60 UV-vis spectrophotometer, FLS920 photoluminescence spectrometer, X-7 series ICP-MS, Netzsch STA 449C TGA system, and RBD upgraded PHI-5000C ESCA system (XPS). Materials included 1,2,4,5-benzenetetracarboxylic acid (H4btec), Al(NO3)3·9H2O, Tb(NO3)3·6H2O, and various chemicals for interference studies.

4：Experimental Procedures and Operational Workflow:

Synthesis of Al(OH)[H2btec] (1) via hydrothermal reaction at 210°C for 24 h, followed by activation. Preparation of Tb3+@1 by stirring compound 1 with Tb(NO3)3·6H2O in ethanol. Characterization using XRD, FTIR, UV-vis, PL, ICP-MS, TGA, and XPS. Sensing experiments involved immersing Tb3+@1 in HVA solutions and measuring fluorescence intensities at 340 nm and 544 nm. Logic gate implementation used normalized intensity values with a threshold of 0.

5：Data Analysis Methods:

5. 5. Data Analysis Methods: Fluorescence intensity ratios (I340 nm/I544 nm) were plotted against HVA concentrations for sensitivity analysis. Limit of detection (LOD) was calculated using the 3σ IUPAC criteria. Statistical analysis included linear regression (R2 = 0.945) and reproducibility checks with triplicate experiments.