- 标题
- 摘要
- 关键词
- 实验方案
- 产品
-
Effects of object-to-detector distance and beam energy on synchrotron radiation phase-contrast imaging of implanted cochleae
摘要： Objectives: To demonstrate that synchrotron radiation phase-contrast imaging (SR-PCI) can be used to visualize the intrascalar structures in implanted human cochleae and to find the optimal combination of the parameters object-to-detector distance (ODD) and beam energy (E) for visualization. Materials and Methods: Three cadaveric implanted human temporal bones underwent SR-PCI with varying combinations of parameters ODD (3, 2 and 1 m) and E (47, 60 and 72 keV). All images were then reconstructed to a three-dimensional (3D) stack of slices. The acquired 3D images were compared using contrast-to-noise ratios (CNRs) of the basilar membrane (CNRBM) and the electrode array (CNRE) and the standard deviation of the beam streaks (σS). Postprocessing calculations were performed using Matlab (Version 2017b, MathWorks Inc., Natick, MA, U.S.A.) with a standard significance level p < 0.05 to determine the most optimal combination of parameters. Results: SR-PCI with computed tomography reconstruction provided good visualization of the anatomical features of the implanted cochleae, specifically the exact location of the electrode with respect to the BM. A single-factor ANOVA revealed a significant difference of variance for both CNRE and CNRBM, but failed to show significance for σS. A two-sample t-test failed to show any significant difference between CNRE columns of (3 m, 72 keV) and (2 m, 60 keV). The CNRBM was significantly different only at two pairs of columns, when (1 m, 72 keV) was compared against (2 m, 72 keV) and (3 m, 72 keV). Conclusions: The results of this study show that SR-PCI is a viable method to visualize implanted human cochleae. SR-PCI is less invasive, less labour intensive and is associated with a much lower acquisition time compared to other methods for postimplantation imaging in humans, such as histological sectioning. We found that the optimal combination of E and ODD parameters was 72 keV and 2 m, respectively. These parameters resulted in high-contrast images of the electrode as well as all internal structures of the cochleae.
关键词： Cochlear implant,phase-contrast imaging,image segmentation,synchrotron radiation
更新于2025-09-10 09:29:36
-
Reference Module in Chemistry, Molecular Sciences and Chemical Engineering || Photoionization
摘要： The ionization of analyte molecules is of vital importance to mass spectrometric analysis because mass spectrometry takes only ions as the object for analysis. The most commonly used ionization source in mass spectrometry is electron-impact (EI) ionization source with electrons impacting to analyte with an energy of 70 eV. The kinetic energy of 70 eV is much higher than the ionization energy of organic molecules, and the ionization process approaches the maximal ionization efficiency. Thus, a large number of fragment peaks are usually observed in an EI mass spectrum. These fragments act as fingerprints of molecules, which can be used for identification of unknown molecules by searching EI-MS library, for example NIST Mass Spectral Library. This statistically based identification is particularly convenient and effective when analyzing a single component, for example a preseparated analyte by GC. However, there are many cases that analytes cannot be preseparated, for example very active components in a reaction, or fast on-line observation of evolving analytes. Consequently, the extensive fragmentation by EI-MS turns to a severe disadvantage: if each compound of a mixture produces a certain amount of fragment peaks, serious interference can be made, which will bring muscular obstacles to peak assignment. The best strategy is to use a “soft” ionization source with high selectivity. Here, “soft” means fragment-free or fragment-controllable.
关键词： SPI,Photoionization,APPI,REMPI,VUV Lamps,Synchrotron Radiation,Lasers,Mass Spectrometry
更新于2025-09-10 09:29:36
-
First measurements of the vertical beam size with an X-ray beam size monitor in SuperKEKB rings
摘要： This paper reports first measurements of the vertical beam size using an X-Ray Beam Size Monitor (XRM) for each of the SuperKEKB rings (Low Energy Ring, LER, and High Energy Ring, HER) during Phase 1 and 2 commissioning of SuperKEKB. The XRM device is dedicated to measuring the e?/e+ vertical beam size using X-ray synchrotron radiation, and will eventually have the capability for single-shot (single bunch, single turn) measurements. The preparation of a deep Si detector and high-speed readout electronics for single-shot measurements is underway. In the meantime for Phase 1 and 2, we used a scintillator screen and CCD camera for multi-bunch measurements. The XRM has been installed in each ring and images X-rays from a bending magnet that pass through optical elements (a single pinhole and coded apertures). Several studies (geometrical scale factors, emittance control knob, and beam lifetime study) were carried out during the commissioning. In Phase 1 (February-June 2016), the measured vertical emittances εy are ～10 pm for LER (consistent with the optical estimation) and ～35 pm for HER (3.5× greater than the optical estimation). Analysis of the beam size and lifetime measurements suggests unexpectedly large point spread functions (PSF), particularly in the HER. The spatial resolution of the imaging system (defect of focus, diffraction, and spherical aberration) and scattering in the beamline (EGS5 simulation) contribute ～6 μm of PSF, which does not adequately account for the observed PSF. The Phase 2 commissioning commenced in May-July 2018, with thinner Be filters, new optical elements, scintillator, and CCD camera with the purpose to reduce the PSF in HER. The Phase 2 study results suggest the PSF σs ～6.6 μm in HER (corresponding to the spatial resolution of the imaging system and scattering in the beamline), which is ～5× smaller than in Phase 1. The overall performances of XRMs in LER and HER are accurate. The XRM in LER will be able to measure the design beam size at the zero current (14 μm). For the HER, the PSF that we observed during the Phase 2 indicates that the minimum measured beam size corresponds to the emittance at the design current (12.9 pm) and the XRM will be able to measure the design beam size at the zero current (7 μm).
关键词： SuperKEKB,synchrotron radiation,vertical beam size,X-ray beam size monitor,coded aperture,pinhole
更新于2025-09-10 09:29:36
-
Transverse resonance island buckets for synchrotron-radiation based electron time-of-flight spectroscopy
摘要： At the Metrology Light Source (MLS), the compact electron storage ring of the Physikalisch-Technische Bundesanstalt (PTB) with a circumference of 48 m, a specific operation mode with two stable closed orbits for stored electrons was realized by transverse resonance island buckets. One of these orbits is closing only after three turns. In combination with single-bunch operation, the new mode was applied for electron time-of-flight spectroscopy with an interval of the synchrotron radiation pulses which is three times the revolution period at the MLS of 160 ns. The achievement is of significant importance for PTB’s future programs of angular-resolved electron spectroscopy with synchrotron radiation and similar projects at other compact electron storage rings. The scheme applied here for selecting the photons originating from a particular orbit by optical imaging has been used before in fs slicing applications and may be relevant for the BESSY VSR project of the Helmholtz-Zentrum Berlin.
关键词： BESSY VSR,transverse resonance island buckets,electron time-of-flight spectroscopy,Metrology Light Source,synchrotron radiation
更新于2025-09-10 09:29:36
-
Ultrafast nuclear dynamics in the doubly-core-ionized water molecule observed via Auger spectroscopy
摘要： We present a combined experimental and theoretical study of the Auger-emission spectrum following double core ionization and excitation of gas-phase water molecules with hard-x-ray synchrotron radiation above the O K ?2 threshold. We observe an indication of ultrafast proton motion occurring within the 1.5 fs lifetime of the double-core-hole (DCH) states in water. Furthermore, we have identi?ed symmetric and antisymmetric dissociation modes characteristic for particular DCH states. Our results serve as a fundamental reference for state-of-the-art studies of DCH dynamic processes in liquid water both at synchrotron and free-electron-laser facilities.
关键词： double core ionization,Auger-emission spectrum,synchrotron radiation,ultrafast proton motion,DCH states
更新于2025-09-09 09:28:46
-
On evaluating x-ray imaging crystals with synchrotron radiation
摘要： Bent crystals used in diagnostics of plasmas combine x-rays diffracted from across the crystal. Therefore imperfections in the resulting 1-D spectrum or 2-D image are not the best way to find out why one particular crystal may differ in its performance from another and what, if anything, to do about it. Instead, here we want to measure the diffraction locally, with the necessary resolution. Nominally monochromatic and unidirectional radiation from the synchrotron’s standard x-ray optics proved to be insufficient for the purpose. Here much better radiation comes from the x-ray topography setup at the x-ray optics testing beamline 1-BM at the Advanced Photon Source, thanks to a specially designed quartz conditioning crystal. Some worrisome features in a bent crystal’s diffraction have thereby disappeared, while minor fabrication flaws remain highly visible.
关键词： x-ray imaging,diffraction,synchrotron radiation,plasma diagnostics,bent crystals
更新于2025-09-09 09:28:46
-
Extreme Ultraviolet to Visible Dispersed Single Photon Detection for Highly Sensitive Sensing of Fundamental Processes in Diverse Samples
摘要： The detection of a single photon is the most sensitive method for sensing of photon emission. A common technique for single photon detection uses microchannel plate arrays combined with photocathodes and position sensitive anodes. Here, we report on the combination of such detectors with grating diffraction spectrometers, constituting a low-noise wavelength resolving photon spectroscopy apparatus with versatile applicability. We recapitulate the operation principle of such detectors and present the details of the experimental set-up, which we use to investigate fundamental mechanisms in atomic and molecular systems after excitation with tuneable synchrotron radiation. Extensions for time and polarization resolved measurements are described and examples of recent applications in current research are given.
关键词： fluorescence,synchrotron radiation,single photon detection,photon spectroscopy,clusters,atomic and molecular physics
更新于2025-09-09 09:28:46
-
In vitro assessments of white-spot lesions treated with NaF plus tricalcium phosphate (TCP) toothpastes using synchrotron radiation micro computed tomography (SR micro-CT)
摘要： Synchrotron radiation micro-computed tomography (SR micro-CT), considered superior to standard polychromatic micro-CT techniques, was used to assess the densities of bovine enamel white-spot lesions (WSL) treated in a 10-day pH cycling model with either: (A) Clinpro Tooth Crème (0.21% NaF plus TCP), (B) Clinpro 5000 (1.1% NaF plus TCP) or (C) Tom’s of Maine (0% NaF) dentifrice. Each day consisted of four 2 min treatments, one 4 h acid challenge (pH=5.0), and immersion in artificial saliva (pH=7.0) between these events. After 10 days, WSL specimens were evaluated for lesion depth using confocal microscopy and lesion density using SR micro-CT with depths ranging from 2.76 to 113.16 μm, in 2.76 μm slice increments. Statistical analyses (Student’s t-test) were performed at the 95% confidence level. SR micro-CT analyses revealed the NaF plus TCP dentifrices improved WSL densities relative to the fluoride-free toothpaste, and is consistent with an earlier study utilizing polychromatic micro-CT. In contrast to previous findings, SR micro-CT analyses also revealed significant differences in WSL densities treated with the two NaF dentifrices at enamel depths of 13.80, 16.56, and 19.32 μm. These findings suggest SR micro-CT may be especially suited for detecting density differences in lesions sensitive to fluoride-driven remineralization processes.
关键词： X-ray linear attenuation coefficient (X-ray LAC),synchrotron radiation micro computed tomography (SR micro-CT),density,Toothpaste,monochromatized X-ray beams,fluoride,remineralization
更新于2025-09-09 09:28:46
-
Electronic states of dibenzo-p–dioxin. A synchrotron radiation linear dichroism Investigation
摘要： The UV absorbance bands of dibenzo-p-dioxin (dibenzo-1,4-dioxin, DD) are investigated by synchrotron radiation linear dichroism (SRLD) spectroscopy on molecular samples aligned in stretched polyethylene. The investigation covers the range 58000–30000 cm–1 (170–330 nm), thereby providing new information on the transitions of DD in the vacuum UV region. The observed polarization data enable experimental symmetry assignments of the observed transitions, leading to revision of previously published assignments by Ljubi? and Sablji? (J. Phys. Chem. A 109 (2005) 8209-8217). In general, the experimental spectra are well predicted by the results of quantum chemical calculations using time-dependent density functional theory (TD–DFT). The observed absorbance in the region 58000–55000 cm–1 (170–180 nm) in the vacuum UV is almost entirely short-axis polarized, in pleasing agreement with the predicted spectrum.
关键词： Dibenzo-p-dioxin,Near and vacuum UV,Stretched polyethylene,Polarization directions,Time-dependent density functional theory (TD-DFT),Synchrotron radiation,Linear dichroism (LD)
更新于2025-09-09 09:28:46
-
Dose response and stability of water equivalent PRESAGE <sup>?</sup> dosimeters for synchrotron radiation therapy dosimetry
摘要： This research investigated the dose response and post-irradiation stability of water-equivalent PRESAGE? dosimeters exposed to synchrotron radiation. Water-equivalent PRESAGE? dosimeters were irradiated up to 1000 Gy in a synchrotron x-ray beam with a mean energy of 95.3 keV. The change in optical density was measured using UV/visible spectrophotometry pre- and post-irradiation using a wavelength of 630 nm. Dose response was found to be approximately linear from 0–200 Gy with saturation occurring above 300 Gy. The post-irradiation stability was determined by measuring the change in optical density at 10, 30, 60, 180, 420 min and 7, 21 and 33 d post-irradiation for three groups of dosimeters stored at different temperatures. Each group had two dosimeters irradiated at 50, 100, 200 and 300 Gy and each group was stored at a different temperature following irradiation: room temperature (22 °C), 4 °C and ?18 °C. The optimal time for readout of the dosimeters varied with the post-irradiation storage temperature. The room temperature group had an optimal time-to-readout of 10 min for maximum signal before fading, while the 4 °C group was reasonably stable from 90 min to 1 week. The ?18 °C group showed the least amount of ongoing post-irradiation development and fading with an optimal readout window from 30 min to 21 d. The intra-batch variation between the mean of each temperature control group was 4.2% at 10 min post-irradiation.
关键词： PRESAGE? dosimeter,synchrotron radiation therapy,UV/Vis spectrophotometry
更新于2025-09-09 09:28:46