摘要： Studies carried out in the last decades have unveiled that the ability to self-assemble is a widespread property among biomolecules. Small nucleic acid moieties or very short peptides are able to generate intricate assemblies endowed with remarkable structural and spectroscopic properties. Here we report structural/spectroscopic characterizations of aggregates formed by nucleobases as well as by Peptide Nucleic Acids (PNA)-peptide conjugates. At high concentration, all studied nucleobases form aggregates characterized by previously unreported fluorescence properties. The conjugation of these bases, as PNA derivatives, to the dipeptide Phe-Phe leads to the formation of novel hybrid assemblies, characterized by an amyloid-like association of the monomers. Although these compounds share the same basic cross-β motif, the nature and the number of PNA units have an important impact both on the level of structural order and on the intrinsic fluorescence of the self-assembled nanostructure.