摘要： Background and Objectives: Laser hair removal is the most common laser therapy and the third most commonly performed procedure with more than one million treatments in United States in 2016. This retrospective study was conducted to assess long‐term efficacy and safety of the 755 nm laser for hair removal. Study Design/Materials and Methods: Nearly, 3,606 laser treatments were performed with the long‐pulsed 755 nm wavelength laser equipped with an epidermal cooling device between 1997 and 2005 and were followed till 2013. Standardized assessments were conducted by two treating physicians and patients at two follow‐up intervals. At first follow‐up, clearance was assessed by two physicians and clearance and satisfaction by patients. At the second follow‐up, patients were assessed if hair clearance sustained compared with the first follow‐up. Results: Nine hundred and forty‐eight patients with Fitzpatrick skin types I–IV were treated with a total of 3,606 laser treatments in this study. The mean age at the beginning of the study was 35 years (±11), 95.1% of patients were female (n = 902) and 4.9% male (n = 46). Five hundred and seventy‐four patients received a minimum of three treatments and an average of 5.31 (3–16) treatments on axilla, back, bikini, breast, abdomen, face, lower extremity, or upper extremity region. First, follow‐up was conducted 3.9 (±1.5) years after the laser treatment. Seventy‐four percent of these final patients received 75–100% clearance as reported by the physician and 48% clearance as reported by the patient. Fifty‐two percent of patients reported slower hair growth and 42% change in hair texture. Ninety percent of patients treated on axilla, 82% treated on the bikini area, and 79% treated on lower extremities experienced 75% or more clearance after three treatments. Facial, as well as breast and abdomen treatments, only showed a 66% and 62%, respectively, after three treatments. For these locations, five and more treatments were needed to achieve a quote of 79% (face) or 80% (breast and abdomen) for a 75–100% clearance. Upper extremity and back treatments did not have enough physician ratings to draw conclusions. Long‐term adverse events were minimal and were all located on the face (one patient scar, four patients herpes infection). Second follow‐up of 173 patients was conducted after 11.5 years (±2.0) and 87.9% of patients reported that their improvement sustained. Conclusions: The long‐pulsed 755 nm alexandrite laser is a safe and efficacious treatment for the reduction of unwanted body hair with permanent results and high patient satisfaction.