研究目的
Investigating the effectiveness of CO2 laser therapy followed by 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in treating adult-onset recurrent respiratory papillomatosis (RRP) and preventing its recurrence.
研究成果
CO2 laser therapy followed by ALA-PDT was effective in treating RRP in this case, with no recurrence observed during the 15-month follow-up period. This suggests that PDT may be a promising adjunct therapy for preventing RRP recurrence, though further research with larger samples and longer follow-up is needed.
研究不足
The study is limited by its single-case design and the relatively short follow-up period of 15 months, which may not be sufficient to conclusively prove the long-term effectiveness of the treatment.
1：Experimental Design and Method Selection:
The study involved a case report of a 27-year-old male patient with RRP treated with CO2 laser therapy followed by ALA-PDT.
2：Sample Selection and Data Sources:
The patient's clinical data, including laryngoscopy images and histopathological examination results, were used.
3：List of Experimental Equipment and Materials:
CO2 laser, ALA hydrochloride powder, self-retaining laryngoscope, and a 635 nm wavelength laser.
4：Experimental Procedures and Operational Workflow:
The neoplasm was removed by CO2 laser under general anesthesia, followed by PDT at the surgical site using ALA and a 635 nm wavelength laser.
5：Data Analysis Methods:
Clinical follow-up and laryngoscopy were used to assess treatment efficacy and recurrence.
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