研究目的
To design a label-free multi-resonant graphene-based biosensor for the detection of composite vibrational fingerprints in the mid-infrared region, enabling simultaneous enhancement and detection of multiple vibrational signals of biomolecules.
研究成果
The proposed MRGB with GNRs can not only work as a refractive index biosensor by detecting a plasmon resonance spectra shift but also identify composite vibrational fingerprints in multiple biomolecules simultaneously due to the resonant coupling between plasmons and molecular vibrations. Moreover, it possesses the independent tuning ability for individual plasmonic resonance, which is significant and flexible in practical sensing applications.
研究不足
The exact sensitivity of MRGB is difficult to calculate due to the rough approximation of the biomolecules. The detection limit is evaluated in an approximation way, which may not be precise.
1：Experimental Design and Method Selection:
The study utilizes periodic graphene nanoribbons (GNRs) as a multi-resonant metasurface. The interaction between mid-infrared light and the graphene metasurface is investigated using COMSOL Multiphysics, solving Maxwell Equations with finite element method (FEM) in frequency domain.
2：Sample Selection and Data Sources:
Protein and lipid molecules are assumed as a thin layer with 8 nm thickness for simulation.
3：List of Experimental Equipment and Materials:
Graphene nanoribbons, SiO2 dielectric layer, Si substrate, and metallic electrodes are used.
4：Experimental Procedures and Operational Workflow:
GNRs are grown by chemical vapor deposition and wet-transferred to the surface of SiO2 dielectric layer. Two bias voltages are applied on the interdigitated GNRs to control the Fermi energies separately.
5：Data Analysis Methods:
The transmittance of MRGB is expressed as T = |S21|^2, where S21 is obtained from user-defined ports in the z-directions.
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