研究目的
Investigating the therapeutic effects of a specific herbal medicine on a particular disease.
研究成果
The IR780-sMnO2-PCM NPs may be a promising type of biocompatible theranostic nanoagent, which is responsive to external laser irradiation and internal tumor microenvironment, showing great potential in enhancing cancer combination therapy.
研究不足
The efficacy of MnO2 in cancer therapy is always related and restricted with the concentration of H2O2 in tumor microenvironment. The pregenerated oxygen may diffuse and be further consumed by cancer cells, thereby reducing the oxygen utilization and limit the PDT effect.
1：Experimental Design and Method Selection:
The study utilized thermal responsive phase change materials (PCM) to coencapsulate ultrasmall manganese dioxide (sMnO2) and organic photosensitizer IR780 for controlled tumor hypoxia modulation and enhanced phototherapy.
2：Sample Selection and Data Sources:
HeLa cells were used for in vitro experiments, and HeLa tumor-bearing nude mice were used for in vivo studies.
3：List of Experimental Equipment and Materials:
Includes PCM, sMnO2, IR780, l-α-Lecithin, DSPE-mPEG, and various instruments for characterization and imaging.
4：Experimental Procedures and Operational Workflow:
Involved the synthesis of IR780-sMnO2-PCM nanoparticles, their characterization, in vitro and in vivo phototherapy experiments, and imaging studies.
5：Data Analysis Methods:
Included UV–vis spectroscopy, fluorescence imaging, photoacoustic imaging, and statistical analysis of therapeutic outcomes.
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