研究目的
To present a method to prepare composite materials that replicate the properties of human kidney stones during laser lithotripsy, addressing the lack of robust artificial stone models.
研究成果
The study concludes that composite materials containing insoluble mineral and organic polymer can replicate the behavior and near-infrared spectral signature of human kidney stones during laser lithotripsy. These materials are superior to current models for assessing clinical lasers and provide insight into the factors determining stone resilience during lithotripsy.
研究不足
The study acknowledges that the microstructure of human kidney stones is not replicated in the artificial stones, and the method of preparation may introduce more void volumes, affecting mechanical stability.
1：Experimental Design and Method Selection:
The study involved preparing composite materials containing a dominant mineral phase compacted with organic polymer to mimic human kidney stones.
2：Sample Selection and Data Sources:
Human kidney stones and artificial stones composed of calcium oxalate monohydrate (COM), uric acid (UA), or magnesium ammonium phosphate hexahydrate (MAPH) were used.
3：List of Experimental Equipment and Materials:
A Lumenis holmium:YAG laser was used for single-pulse laser lithotripsy experiments.
4：Experimental Procedures and Operational Workflow:
Single-pulse experiments were performed on flat human stone samples and flat artificial stones in a water bath to mimic conditions in the urinary tract.
5：Data Analysis Methods:
The volume of ablated material after a single holmium:YAG pulse was measured to quantify the extent of fragmentation.
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