研究目的
To characterize changes in nuclear, cortical, and posterior subcapsular lens opacities after selective laser trabeculoplasty (SLT) in Afro-Caribbean eyes with primary open-angle glaucoma (POAG).
研究成果
Selective laser trabeculoplasty was not associated with clinically significant changes in nuclear, cortical, or posterior subcapsular lens opacities in glaucomatous Afro-Caribbean eyes. The rate of cataract surgery in the WIGLS is consistent with reported rates from longitudinal natural history studies performed in Caribbean and non-Caribbean populations.
研究不足
The economic burden of having cataract surgery might render the observed rate of cataract surgery an underrepresentation of the rate of visually significant cataract development. The analysis was limited to eyes having a single SLT treatment.
1：Experimental Design and Method Selection:
Prospective case series design to evaluate changes in lens opacities after SLT in Afro-Caribbean eyes with POAG.
2：Sample Selection and Data Sources:
72 patients (142 phakic eyes) with POAG in the West Indies Glaucoma Laser Study (WIGLS) were evaluated.
3：List of Experimental Equipment and Materials:
Selective laser trabeculoplasty was performed using a Selecta II portable slitlamp-mounted laser system (Lumenis).
4：Experimental Procedures and Operational Workflow:
Patients had 360-degree SLT after medication washout. Lens opacities were graded using the Lens Opacification Classification System III (LOCS III) at baseline and 12, 24, and 36 months after SLT.
5：Data Analysis Methods:
Changes in opacity scores from baseline were evaluated using paired t tests.
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