研究目的
To compare the ability of selective laser trabeculoplasty (SLT) in preventing glaucoma progression in the initial primary angle-closure glaucoma (PACG) after laser peripheral iridotomy and primary open-angle glaucoma (POAG) in the long term.
研究成果
SLT is an effective treatment for initial PACG after LPI and POAG that can prevent functional and structural deterioration in the long term. It significantly reduces IOP and the rate of glaucoma progression in both groups.
研究不足
The study observed only patients with an initial stage of primary glaucoma. The rate of visual field deterioration was assessed based on perimetry data before laser treatment, and the study did not adjust for normal age-related structural thinning and OCT signal strength index in GCC and RNFL trend analysis.
1：Experimental Design and Method Selection
A prospective study was conducted to compare the efficacy of SLT in preventing glaucoma progression in PACG after laser peripheral iridotomy and POAG. The study included trend and event analysis of perimetry, Guided Progression Analysis, and OCT-based negative trend analysis for RNFL and GCC thickness.
2：Sample Selection and Data Sources
60 patients with initial PACG after laser peripheral iridotomy and 64 initial POAG patients were recruited. Patients were selected based on specific inclusion criteria, including the stage of glaucoma and the absence of certain eye conditions.
3：List of Experimental Equipment and Materials
Equipment used included the Humphrey perimeter (Carl-Zeiss Meditec, Dublin, CA) for standard automated perimetry, FD-OCT (RTVue, Optovue, Inc., Fremont, CA, USA) for imaging and measuring peripapillary NFL and macular GCC, and Lasersx Solo ND:YAG laser (Ellex Medical Lasers Limited, Adelaide, Australia) for SLT.
4：Experimental Procedures and Operational Workflow
SLT was performed under topical anesthesia using the Latina lens. Power was initially set at 0.6 mJ and increased until small bubbles appeared from the treated area. Nonoverlapping laser applications were performed over 180–360° of the trabecular meshwork. Patients were followed up every four months annually for up to 6 years.
5：Data Analysis Methods
Statistical analysis was performed using the Statistical Package for Social Sciences (SPSS) 16.0 for Windows. The mean and proportions were compared using Student’s t-test and the X2 test. The Mann–Whitney U test was used for differences in progression rates. The Kaplan–Meier survival analysis was used to assess the likelihood of continued IOP control.
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