研究目的
To investigate the differences in neurovascular coupling between Caucasian patients with normal tension glaucoma (NTG) and healthy subjects (HS) with Laser Speckle Flowgraphy (LSFG).
研究成果
Neurovascular coupling is detectable in NTG patients. Flicker light stimulation leads to a comparable increase in ocular blood flow in glaucoma patients and healthy individuals. It seems that neurovascular coupling is generally reduced in elderly subjects, even without signs of glaucoma.
研究不足
The study included only twelve subjects per group as this study was conducted as a pilot study. This inhibited further subgroup analysis as to e.g. whether the degree of glaucomatous damage is correlated with changes in neurovascular coupling. Furthermore, participants in the current trial were all on a PGA monotherapy.
1：Experimental Design and Method Selection:
Measurement of optic nerve head blood flow was performed with LSFG during continuous flicker light stimulation for four minutes.
2：Sample Selection and Data Sources:
Included 12 eyes from 12 Caucasian patients with diagnosis of normal tension glaucoma and 12 eyes from 12 age- and sex-matched healthy individuals.
3：List of Experimental Equipment and Materials:
LSFG RetFlow device (Nidek Co., LTD, Gamagori, Aichi, Japan), custom-built external illumination unit with a white light-emitting diode (LED).
4：Experimental Procedures and Operational Workflow:
After a resting period of 10 minutes the baseline LSFG measurement was performed. Diffuse luminance flicker illumination was then applied for 4 minutes with repeated LSFG measurements at each minute.
5：Data Analysis Methods:
Statistical analyses were conducted using SPSS software version 23.0 (SPSS Inc., Chicago, IL, USA).
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